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  • Title: Recent progress in osteogenesis imperfecta.
    Author: Zhao X, Yan SG.
    Journal: Orthop Surg; 2011 May; 3(2):127-30. PubMed ID: 22009598.
    Abstract:
    Osteogenesis imperfecta (OI), a rare clinical disease with abnormal type I collagen, is inherited or caused by mutation. A classification of OI into four types was proposed in 1979 and has been used up until four new types were added recently. A tough clinical challenge, OI causes abnormal blood coagulation and cardiovascular structure, airways obstruction, and delayed wound healing. The authors of the current article have reviewed recent progress in OI worldwide, including the mechanisms, classification, detection, clinical difficulties, and treatment.
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