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  • Title: Biological evaluation of glucose and deoxyglucose derivatives radiolabeled with [99mTc(CO)3(H2O)3]+ core as potential melanoma imaging agents.
    Author: Dapueto R, Castelli R, Fernández M, Chabalgoity JA, Moreno M, Gambini JP, Cabral P, Porcal W.
    Journal: Bioorg Med Chem Lett; 2011 Dec 01; 21(23):7102-6. PubMed ID: 22014828.
    Abstract:
    Glucose 9 and 2-deoxyglucose 10 were successfully synthesized and radiolabeled with [(99m)Tc(CO)(3)(H(2)0)(3)](+) intermediate in high yield. The complexes were characterized by HPLC and its stability with histidine over time was challenged. Cell uptake and biodistribution studies in melanoma-bearing C57BL/6 mice were performed. Both compounds showed accumulation in tumor tissue with high tumor-to-muscle ratios. Thus, D-glucose- and D-2-deoxyglucose-(99m)Tc complex could be considered as agents for melanoma diagnosis.
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