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  • Title: Stimulation of p21ras upon T-cell activation.
    Author: Downward J, Graves JD, Warne PH, Rayter S, Cantrell DA.
    Journal: Nature; 1990 Aug 23; 346(6286):719-23. PubMed ID: 2201921.
    Abstract:
    External signals that control the activity of proteins encoded by the ras proto-oncogenes have not previously been characterized. It is now shown that stimulation of the antigen receptor of T lymphocytes causes a rapid activation of p21ras. The mechanism seems to involve a decrease in the activity of GAP, the GTPase-activating protein, on stimulation of protein kinase C. In lymphocytes, p21ras may therefore be an important mediator of the action of protein kinase C.
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