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  • Title: Transcranial magnetic stimulation and peristimulus frequencygram.
    Author: Todd G, Rogasch NC, Türker KS.
    Journal: Clin Neurophysiol; 2012 May; 123(5):1002-9. PubMed ID: 22019353.
    Abstract:
    OBJECTIVE: The aim of our study was to use peristimulus frequencygram (PSF) constructed from single motor unit recordings to further characterise the responses evoked by low intensity TMS. METHODS: Twelve healthy subjects (age 32 ± 11 years) received single-pulse TMS over the first dorsal interosseus (FDI) motor area during weak isometric index finger abduction. Several hundred stimuli were delivered at a frequency of ∼0.3 Hz and at an intensity of 79-110% of active motor threshold. FDI electromyogram (EMG) was recorded with surface and intramuscular fine wire electrodes. For single motor units, data analysis involved construction of a peristimulus time histogram (PSTH) and PSF. Surface EMG analysis involved signal averaging. Cumulative sums (CUSUMs) were calculated for SEMG, PSTH, and PSF data. RESULTS: Forty-five single motor units were identified. The average number of stimuli per unit was 201 ± 112. Characterisation of the response evoked by TMS differed with the use of SEMG, PSTH, and PSF CUSUMs. CONCLUSIONS: The duration of the EMG silence that follows the MEP during voluntary contraction was longer in the PSF than SEMG and PSTH. SIGNIFICANCE: These findings highlight the importance of using both probability and frequency-based analysis when determining the duration of inhibitory events in peripheral recordings.
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