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  • Title: Formulation and development of taste masked fast-disintegrating tablets (FDTs) of Chlorpheniramine maleate using ion-exchange resins.
    Author: Yewale CP, Rathi MN, Kore GG, Jadhav GV, Wagh MP.
    Journal: Pharm Dev Technol; 2013; 18(2):367-76. PubMed ID: 22023351.
    Abstract:
    CONTEXT: Masking of bitter taste of drug for better patient compliance. OBJECTIVE: The objective of this research was to mask the bitter taste of Chlorpheniramine maleate using cation exchange resins. MATERIALS AND METHODS: Different cation exchange resins were used for taste masking. The drug resin complexes (DRC) were prepared by batch process. Complexes of ion-exchange resin and Chlorpheniramine maleate were prepared by taking drug: resin ratios 1:1, 1:2, 1:3 and 1:4 (w/w). The optimum drug:resin ratio and the time required for maximum complexation was determined. The drug resinates were evaluated for the drug content, taste, drug release, FTIR, DSC and X-ray diffraction (PXRD). RESULTS AND DISCUSSION: The X-ray diffraction study confirmed the monomolecularity of entrapped drug in the resin beads. The taste evaluation depicted the successful taste masking of Chlorpheniramine maleate with DRCs. Fast disintegrating tablets (FDTs) were developed depending upon percent complexation, release study at salivary and gastric pH, taste evaluation; Chlorpheniramine maleate: Indion-234 complex of ratio 1:2 was used to develop and formulate FDTs. The drug release of 94.77% in 30 min was observed from FDTs. CONCLUSION: The Effective taste masking can be obtained from DRC that can be formulated as FDTs for better patient compliance.
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