These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Pathogenesis of corticoid-induced osteoporosis].
    Author: Ringe JD.
    Journal: Fortschr Med; 1990 Jul 10; 108(20):393-6. PubMed ID: 2202618.
    Abstract:
    Corticoid osteoporosis is the most important of the so-called secondary forms of osteoporosis. Although, in recent years, our knowledge of the pathomechanisms involved have been expanded, at the cellular and molecular-biological level, it remains incomplete. In practical-clinical terms, however, the following main effects of corticoids on bone metabolism and the calcium balance can be identified: inhibition of osteoblastic bone matrix synthesis and enhancement of osteoclastic bone absorption. This latter is promoted by inhibition of intestinal calcium absorption and tubular reabsorption of calcium with subsequent mild secondary hyperparathyroidism. These mechanisms suggest possibilities for the prevention and treatment of this form of osteoporosis.
    [Abstract] [Full Text] [Related] [New Search]