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  • Title: Randomised double blind placebo controlled clinical trial of sucralfate and ranitidine in chronic duodenal ulcer.
    Author: Nair KV, Ramachandran TM, Thomas V, Rajindranath T.
    Journal: J Assoc Physicians India; 1990 Mar; 38(3):211-2. PubMed ID: 2202705.
    Abstract:
    A double blind, randomised, placebo controlled clinical trial was carried out in endoscopically proved chronic duodenal ulcer patients to compare the efficacy of sucralfate and ranitidine. Sucralfate 1 g four times daily and ranitidine 150 mg twice daily were found to be equally effective in inducing ulcer healing (73.1% and 82.1% respectively) during the 6-week treatment period. The rate of recurrence of the ulcer within six months after the initial treatment (84.2% and 82.6%) was also comparable in the sucralfate and ranitidine groups. Sucralfate and ranitidine are equally effective in ulcer healing and prevention of ulcer relapse.
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