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  • Title: Acquired haemophilia A in a woman with autoimmune hepatitis and systemic lupus erythematosus; review of literature.
    Author: Rezaieyazdi Z, Sharifi-Doloui D, Hashemzadeh K, Shirdel A, Mansouritorghabeh H.
    Journal: Blood Coagul Fibrinolysis; 2012 Jan; 23(1):71-4. PubMed ID: 22027758.
    Abstract:
    Acquired haemophilia A, secondary to systemic lupus erythematosus (SLE) is a rare bleeding diathesis. Here we report a 37-year-old woman with autoimmune hepatitis who developed SLE and acquired haemophilia caused by factor VIII inhibitors. She presented with spontaneous ecchymosis and haematuria. There were a prolongation of the activated partial thromboplastin time, reduced factor VIII activity and a high titer of FVIII inhibitors. Therapeutic regimen was started with intravenous methylprednisolone pulse, continued with prednisolone, intravenous pulse cyclophosphamide and fresh frozen plasma. After 8 weeks, factor VIII inhibitor assay was negative.
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