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  • Title: [Phosphodiesterase-4 inhibitors: a new target in treatment of COPD].
    Author: Michels G, Erdmann E, Pfister R.
    Journal: Dtsch Med Wochenschr; 2011 Nov; 136(44):2267-70. PubMed ID: 22028292.
    Abstract:
    Roflumilast is a new drug with innovative pharmacodynamic properties for use in patients with chronic obstructive pulmonary disease (COPD). By selective inhibition of phosphodiesterase-4 roflumilast targets inflammatory processes in COPD, with beneficial effects on smoking-induced bronchial inflammation, fibrotic remodeling, mucociliary malfunction and oxidative stress.
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