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  • Title: Identification of a novel sildenafil analogue in an adulterated herbal supplement.
    Author: Vaysse J, Gilard V, Balayssac S, Zedde C, Martino R, Malet-Martino M.
    Journal: J Pharm Biomed Anal; 2012 Feb 05; 59():58-66. PubMed ID: 22030075.
    Abstract:
    iErect, a new dietary supplement marketed as "100% natural" and sold over the Internet, was analyzed. It contains thiosildenafil, a sildenafil analogue already reported as an adulterant in herbal formulations, and a new compound whose structure was elucidated after isolation using NMR, MS and IR. It was named depiperazinothiosildenafil as it results from the hydrolytic cleavage of the S-N bond of the sulfonamide group of thiosildenafil. A capsule of iErect contains a very high amount (≈220mg) of thiosildenafil and ≈30mg of depiperazinothiosildenafil, which places consumers at risk for potentially serious side-effects.
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