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  • Title: Advantage of higher-avidity CTL specific for Tax against human T-lymphotropic virus-1 infected cells and tumors.
    Author: Kitazono T, Okazaki T, Araya N, Yamano Y, Yamada Y, Nakamura T, Tanaka Y, Inoue M, Ozaki S.
    Journal: Cell Immunol; 2011; 272(1):11-7. PubMed ID: 22030472.
    Abstract:
    Strong CTL response can be observed and associated with the control of proviral load in human T-lymphotropic virus type 1 (HTLV-1) infection. However, there are few details with regard to how HTLV-1 specific CTLs work against HTLV-1 infected cells and adult T-cell leukemia cells (ATLs). In this study, using Tax-specific CTL lines with high- and low-functional avidity developed from HLA-A2-transgenic mice, we showed that higher avidity CTLs specific for Tax expressing larger numbers of TCRs and better binding strength to the antigen-HLA-A2 complex are much more efficient at eliminating HTLV-1 infected cells and, in particular, ATL tumor cells with the ability of recognizing a latent level of Tax product detected only with a real-time PCR. These findings suggest that such higher avidity CTLs specific for Tax in HTLV-1 could be responsible for preventing the development of HTLV-1 infection by detecting trace amount of antigens.
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