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  • Title: [Surgical treatment and prognosis of gastrointestinal stromal tumor].
    Author: Lu ZH, Wu XJ, Fang YJ, Pan ZZ, Wan DS.
    Journal: Zhonghua Wei Chang Wai Ke Za Zhi; 2011 Oct; 14(10):778-80. PubMed ID: 22030776.
    Abstract:
    OBJECTIVE: To investigate the outcome of surgical treatment for gastrointestinal stromal tumor(GIST) and the associated factors. METHODS: A total of 277 patients with GIST underwent primary surgical treatment from January 1990 to February 2010 at the Cancer Center of Sun Yat-sen University. The clinical data were retrospectively reviewed and the pathological examination was reviewed. Follow-up was performed. RESULTS: There were 176 males and 101 females. The age ranged from 20 to 81 years old (median,57). Location of the tumor included colorectum (n=28),small bowel(n=76), stomach(n=173). All the patients had en bloc resection, including local excision in 98 patients, organ resection in 64, and extended resection in 115. The 5-year survival rates were 83.5%, 71.9%, and 61.9% in the three different procedures, respectively, and the difference was not statistically significant(P>0.05). Cox model showed that the tumor size, recurrence and metastasis were independent risk factors associated with the prognosis in GIST patients(P<0.05). CONCLUSIONS: Surgery remains the major approach for gastrointestinal GIST. Complete resection is the principal treatment. Extensive resection or extended lymph nodes dissection is not associated with improved survival.
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