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  • Title: Abnormal streak gonads in 46,XY complete gonadal dysgenesis.
    Author: Doherty LF, Rackow BW.
    Journal: Fertil Steril; 2011 Dec; 96(6):1415-6. PubMed ID: 22032815.
    Abstract:
    OBJECTIVE: To describe the surgical findings in two adolescents with 46,XY complete gonadal dysgenesis. DESIGN: Report of two cases. SETTING: University teaching hospital. PATIENT(S): Two adolescents with 46,XY complete gonadal dysgenesis who underwent laparoscopic bilateral gonadectomy. INTERVENTION(S): Laparoscopic bilateral gonadectomy. MAIN OUTCOME MEASURE(S): Removal of dysgenetic gonads. RESULT(S): One benign fibrothecoma and one gonadoblastoma were identified upon pathologic evaluation of the streak gonads. CONCLUSION(S): Individuals with 46,XY complete gonadal dysgenesis are at risk for malignant transformation of the dysgenetic gonads. Because the risk of malignancy is approximately 30%, prompt gonadectomy should be performed after diagnosis of 46,XY complete gonadal dysgenesis.
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