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  • Title: Cloning of the p50 DNA binding subunit of NF-kappa B: homology to rel and dorsal.
    Author: Ghosh S, Gifford AM, Riviere LR, Tempst P, Nolan GP, Baltimore D.
    Journal: Cell; 1990 Sep 07; 62(5):1019-29. PubMed ID: 2203532.
    Abstract:
    The DNA binding subunit of the transcription factor NF-kappa B, p50, has been cloned. p50 appears to be synthesized as a larger protein that is then processed to its functional size. Sequence analysis reveals remarkable homology for over 300 amino acids at the amino-terminal end to the oncogene v-rel, its cellular homolog c-rel, and the Drosophila maternal effect gene dorsal. This establishes NF-kappa B as a member of the rel family of proteins, all of which display nuclear-cytosolic translocation. Protein sequence from the p65 polypeptide has established that it is not encoded in the same mRNA as p50. However, p65 appears homologous to c-rel, suggesting that c-rel may form heterodimers with p50 and rel may include a homodimerization motif.
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