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  • Title: Highly enantioselective one-pot synthesis of spirocyclopentaneoxindoles containing the oxime group by organocatalyzed Michael addition/ISOC/fragmentation sequence.
    Author: Li X, Li YM, Peng FZ, Wu ST, Li ZQ, Sun ZW, Zhang HB, Shao ZH.
    Journal: Org Lett; 2011 Dec 02; 13(23):6160-3. PubMed ID: 22050288.
    Abstract:
    A highly diastereo- and enantioselective organocatalytic protocol for the synthesis of biologically important spirocyclopentaneoxindoles containing the oxime functional group from easily accessible 3-allyl-substituted oxindoles and nitroolefins has been developed by a one-pot Michael addition/ISOC/fragmentation sequence.
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