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  • Title: Promoter of TFPI-2 is hypermethylated in Chinese pediatric acute myeloid leukemia.
    Author: Jian P, Yan WS, Chao SL, Liang P, Zhen L, Ling QB, Hong LY, Ping LY, Jian W, Fang JM, Ling L, Dong WX, Ming ZX, Jian N.
    Journal: J Pediatr Hematol Oncol; 2012 Jan; 34(1):43-6. PubMed ID: 22052167.
    Abstract:
    Human tissue factor pathway inhibitor-2 (TFPI-2) has been implicated as a metastasis-associated gene in many types of tumors. In this study, we investigated whether TFPI-2 was inactivated epigenetically in pediatric acute myeloid leukemia (AML). Methylation status was investigated by methylation-specific polymerase chain reaction and bisulfate genomic sequencing. TFPI-2 was aberrantly methylated in 50% (3/6) of AML cell lines. Aberrant methylation of TFPI-2 promoter was detected in 71.6% (48/67) of the Chinese pediatric AML patients. TFPI-2 transcript was significantly lower in AML group compared with controls (3.44 vs. 32.8, P<0.001). Patients with methylated TFPI-2 gene had significantly lower TFPI-2 transcript than those patients without methylated TFPI-2 (P=0.04). Promoter hypermethylation of TFPI-2 is frequent and specific event in pediatric AML.
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