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  • Title: Significant association of SRC protein expression with the progression, recurrence, and prognosis of oral squamous cell carcinoma in Taiwan.
    Author: Cheng SJ, Kok SH, Lee JJ, Yen-Ping Kuo M, Cheng SL, Huang YL, Chen HM, Chang HH, Chiang CP.
    Journal: Head Neck; 2012 Sep; 34(9):1340-5. PubMed ID: 22052839.
    Abstract:
    BACKGROUND: Src protein overexpression correlates with progression and prognosis of a variety of human cancers. METHODS: This study used immunohistochemistry to examine the expression of Src protein in 93 specimens of oral squamous cell carcinoma (OSCC). RESULTS: We found a significant association of high expression of Src protein (labeling indices >50%) with larger tumor size (p = .017), positive lymph node metastasis (p = .030), more advanced clinical stages (p = .007), and recurrence (p < .001) of OSCC. High expression of Src protein was identified as an independent unfavorable prognosis factor by multivariate Cox regression analysis. The Kaplan-Meier curve showed that patients with OSCC with high expression of Src protein had a significantly poorer cumulative survival than those with low expression of Src protein (log-rank test, p = .00267). CONCLUSION: The expression of Src protein is significantly associated with the progression, recurrence, and prognosis of OSCCs in Taiwan.
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