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  • Title: Peripheral neuropathy in lead-intoxicated sickle cell patients.
    Author: Imbus CE, Warner J, Smith E, Pegelow CH, Allen JP, Powars DR.
    Journal: Muscle Nerve; 1978; 1(2):168-71. PubMed ID: 220532.
    Abstract:
    Peripheral neuropathy and hypertension caused by lead intoxication are reported in two children with sickle cell anemia. One child had generalized weakness in the initial occurrence and distal paralysis during a relapse two years later. The second child had foot and wrist drop. Both had slow peripheral nerve conduction velocities during the episodes. Chelation therapy was successful and resulted in a return of strength (over a period of several months) and a normalization of the blood pressures. Children with sickle cell anemia who are subjected to lead intoxication appear to be predisposed to peripheral nerve damage.
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