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  • Title: Immunocytochemical study of pepsinogen 1-producing cells in the fundic mucosa of the stomach in developing mice.
    Author: Kataoka K, Takeoka Y, Furihata C.
    Journal: Cell Tissue Res; 1990 Aug; 261(2):211-7. PubMed ID: 2205392.
    Abstract:
    Development and maturation of pepsinogen 1-producing cells were studied in the gastric fundic mucosa of the mouse by means of light- and electron-microscopic immunocytochemistry using rabbit anti-rat pepsinogen 1-serum. In the adult mouse, secretory granules in mucous neck cells, transitional mucous neck/chief cells and chief cells are immunolabeled. The numerical density of gold particles on zymogen granules is not significantly altered among different stages of maturation of chief cells. In addition, rough endoplasmic reticulum and Golgi complex of these cell types show a weak labeling. In mice from day 16 of gestation to postnatal day 14, mucous neck cells and chief cells cannot be distinguished, but only one type of pepsinogen 1-producing cell, called 'primitive chief cell', is identified in the fundic gland. The intensity of immunoreactivity of secretory granules in primitive chief cells is uniform within an individual cells but varies greatly among different cells. The majority of primitive chief cells contains weakly labeled granules regardless of the maturation stage of cells or of animals. On postnatal day 21, mucous neck, transitional and chief cells are distinguishable, and secretory granules in these cells are intensely immunolabeled as in the adult. These results suggest that pepsinogen 1-production rapidly increases with differentiation of mucous neck and chief cells.
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