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  • Title: A new 9-nor-atractylodin from Atractylodes lancea and the antibacterial activity of the atractylodin derivatives.
    Author: Chen Y, Wu Y, Wang H, Gao K.
    Journal: Fitoterapia; 2012 Jan; 83(1):199-203. PubMed ID: 22061661.
    Abstract:
    A new compound, namely, 9-nor-atractylodin (1) and one known atractylodin (2) were isolated from the rhizomes of Atractylodes lancea. The structural modifications of atractylodin were carried out and a series of atractylodin derivatives (3-10) were obtained. The antibacterial activities of 1-10 were examined against Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Candida albicans. Compounds 4 and 8, which contained the α, β-unsaturated carbonyl fragment, were found to be active against E. coli and S. aureus.
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