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  • Title: Electrochemical behavior of azithromycin at graphene and ionic liquid composite film modified electrode.
    Author: Peng JY, Hou CT, Liu XX, Li HB, Hu XY.
    Journal: Talanta; 2011 Oct 30; 86():227-32. PubMed ID: 22063535.
    Abstract:
    An electrochemical method has been successfully demonstrated for sensitive determination of azithromycin (Azi) with room temperature ionic liquid (IL) of 1-butyl-3-methylimidazolium hexafluorophosphate (BMIMPF(6)) - graphene (Gr) composite modified glassy carbon electrode (GCE). The cyclic voltammetric results indicate that Gr/IL/GCE can remarkably enhance electrocatalytic activity towards the oxidation of Azi in neutral solutions. Azi produce an anodic peak at about 0.82 V at this electrode. The electrocatalytic behavior was further exploited as a sensitive detection scheme for the Azi determination by differential-pulse voltammetry (DPV). Under optimized conditions, the concentration range and detection limit were 0.49-28.57 μg ml(-1) and 0.19 μg ml(-1) (S/N=3) respectively for Azi. The method was successfully applied assay of the drug in the pharmaceutical dosage forms.
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