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  • Title: Synthesis and enantioseparation characteristics of a novel mono-6-deoxy-(2,4-dihydroxybenzimide)-β-cyclodextrin as a chiral stationary phase in high-performance liquid chromatography.
    Author: Li X, Zhou Z, Dai L, Zhou W, Wang J.
    Journal: Talanta; 2011 Oct 30; 86():452-6. PubMed ID: 22063566.
    Abstract:
    A novel chiral selector mono-6-deoxy-(2,4-dihydroxybenzimide)-β-CD (MDHB-β-CD) in which the derivatized group and the cavity of CD is linked by CH(2)-N=C group, was successfully prepared, and the structural characteristics were determined by FT-IR, (1)H and (13)C NMR, MALDITOF-MS and element analysis. The corresponding stationary phase (CSP) was used in HPLC and the enantioseparation performance was investigated using chiral 1-phenyl-2-nitroethanol derivatives as test samples in the reverse-phase mode composed of methanol/water and acetonitrile/TEAA. Better separation abilities and excellent enantioselectivities (α>1.26, R(S)>1.73) were obtained on MDHB-β-CD CSP for these chiral compounds in the methanol/water mobile phase.
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