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  • Title: Activation of the human leukocyte proteinases elastase and cathepsin G by various surfactants.
    Author: Wenzel HR, Feldmann A, Engelbrecht S, Tschesche H.
    Journal: Biol Chem Hoppe Seyler; 1990 Aug; 371(8):721-4. PubMed ID: 2206460.
    Abstract:
    A systematic study comprising 28 synthetic ionic and nonionic surfactants was carried out in order to examine their effect on the activity of elastase and cathepsin G from human leukocytes against 4-nitroanilide substrates. The whole spectrum, ranging from a complete loss to a pronounced rise in enzymatic activity, was observed at a 0.1% (w/v) surfactant concentration. Most significantly, benzalkonium chloride led to a five-fold increase in elastase activity.
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