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  • Title: Vascular endothelial growth factor polymorphisms are involved in the late vascular complications in Type II diabetic patients.
    Author: Bleda S, De Haro J, Varela C, Esparza L, Ferruelo A, Acin F.
    Journal: Diab Vasc Dis Res; 2012 Jan; 9(1):68-74. PubMed ID: 22064697.
    Abstract:
    AIM: To determine the potential genotype differences in the vascular endothelial growth factor (VEGF) gene in diabetic patients, which might explain the difference in terms of the development of clinical vascular complications: great vessels atherosclerosis vs. retinopathy. METHODS: Genotyping of the VEFG gene insertion/deletion -2549, the C-2578A and the G+405C polymorphisms was done in 40 diabetic patients (26 with peripheral artery disease (PAD) and 14 with diabetic retinopathy (DR)). RESULTS: There was a significant increase in the frequency of the VEGF -2549 DD genotype in PAD patients compared with the DR group (34.6 vs. 0; p = 0.016), as well as in the distribution of the VEGF -2549 ID genotype in DR compared with PAD patients (85.7 vs. 38.4; p = 0.005). There was a significant increase in the frequency of the VEGF -2578 CC genotype in the PAD group compared with DR (34.6 vs. 0; p = 0.016), as well as in the VEGF -2578 CA genotype in DR patients compared with PAD (85.7 vs. 34.6; p = 0.002). The VEGF +405 genotype was not associated with diabetic vascular complications. CONCLUSION: This study provides preliminary evidence that VEGF polymorphisms are associated with a differential presentation of diabetic vascular complications.
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