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  • Title: Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells.
    Author: Hur YH, Kim HH, Seoung JS, Seo KW, Kim JW, Jeong YY, Lee JH, Koh YS, Kim JC, Kim HJ, Cho CK.
    Journal: J Korean Surg Soc; 2011 Aug; 81(2):146-50. PubMed ID: 22066115.
    Abstract:
    Undifferentiated carcinoma with osteoclast-like giant cells is a rare neoplasm of the exocrine pancreas. Some similar cases have been reported, but the histogenesis of these tumors varies and is controversial. We report here on a case of undifferentiated carcinoma of the pancreas with osteoclast-like giant cells. A 77-year old woman presented with abdominal pain and anorexia. Abdominal computed tomography and magnetic resonance imaging showed an approximately 10 × 5 cm highly attenuated mass arising from the tail of the pancreas and invading the spleen and adjacent bowel loop. The initial impression was a malignant endocrine tumor or solid-pseudopapillary tumor of the pancreas. The patient underwent a distal pancreatectomy with splenectomy and left hemicolectomy. The histopathology and immunohistochemistry helped make the diagnosis that of an undifferentiated carcinoma with osteoclast-like giant cells of the pancreas.
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