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  • Title: Levosimendan in two neonates with ischemic heart failure and pulmonary hypertension.
    Author: De Carolis MP, Piastra M, Bersani I, Pardeo M, Stival E, Tempera A, Romagnoli C, Conti G, De Rosa G.
    Journal: Neonatology; 2012; 101(3):201-5. PubMed ID: 22067520.
    Abstract:
    We report the successful and safe use of levosimendan, a new calcium-sensitizing agent with positive inotropic and vasodilatory action, in 2 critically ill term newborns with acute heart failure and pulmonary hypertension in the absence of any underlying heart malformation and/or previous cardiosurgical procedures. During the neonatal period, levosimendan may represent an ideal drug for immature myocardium characterized by a higher calcium-dependent contractility than in adults.
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