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  • Title: Green chemistry: solvent- and metal-free Prins cyclization. Application to sequential reactions.
    Author: Clarisse D, Pelotier B, Piva O, Fache F.
    Journal: Chem Commun (Camb); 2012 Jan 04; 48(1):157-9. PubMed ID: 22068454.
    Abstract:
    Prins cyclization between a homoallylic alcohol and an aldehyde, promoted by trimethylsilyl halide, afforded 4-halo-tetrahydropyrans with good to excellent yields. Thanks to the absence of the solvent and metal, the THP thus obtained have been implicated without purification in several other reactions, in a sequential way, affording in particular new indole derivatives.
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