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  • Title: Profile of inflammatory mediators in gestational diabetes mellitus: phenotype and genotype.
    Author: Gueuvoghlanian-Silva BY, Torloni MR, Mattar R, de Oliveira LS, Scomparini FB, Nakamura MU, Daher S.
    Journal: Am J Reprod Immunol; 2012 Mar; 67(3):241-50. PubMed ID: 22070425.
    Abstract:
    PROBLEM: Our study aimed to assess in vitro production of IL-10, IL-6, TNF-A, and adiponectin serum levels in pregnant women with and without gestational diabetes mellitus (GDM) and to investigate a possible association between GDM and IL-10-1082 A>G (rs1800896), IL-6-174 G>C (rs1800795), TNF-A-308 G>A (rs1800629), adiponectin +45 T>G (rs2241766), and adiponectin-11377 C>G (rs266729) gene polymorphisms. METHOD OF STUDY: This case-control study included 79 women with GDM and 169 healthy controls (C) grouped according to pre-pregnancy BMI. IL-10, IL-6, and TNF-A culture supernatant and adiponectin serum levels were assessed by ELISA. DNA genotype was performed by PCR-RFLP. RESULTS: Adiponectin levels were significantly higher in C than GDM women, even within the same BMI category. Cytokines levels were similar between the groups. There were no associations between GDM and the analyzed gene polymorphisms. CONCLUSIONS: Women with GDM have significantly lower adiponectin levels in the third trimester, regardless of BMI.
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