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  • Title: The extension of polyphenylalanine and polylysine peptides on Escherichia coli ribosomes.
    Author: Hardesty B, Picking WD, Odom OW.
    Journal: Biochim Biophys Acta; 1990 Aug 27; 1050(1-3):197-202. PubMed ID: 2207144.
    Abstract:
    Fluorescence techniques were used to examine aminoacyl-tRNA binding to Escherichia coli ribosomes and the subsequent extension of polyphenylalanine and polylysine nascent peptides. The results demonstrate that deacylated tRNA, an analogue of peptidyl-tRNA and puromycin (an analogue of aminoacyl-tRNA) can be bound simultaneously to the same ribosome. Moreover, the fluorescence properties of nascent polyphenylalanine and polylysine peptides with a fluorophore attached to their amino termini were determined and found to be quite different. This difference is reflected in the effects that erythromycin has in each case.
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