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  • Title: The three-dimensional structure and function of Escherichia coli ribosomal RNA, as studied by cross-linking techniques.
    Author: Brimacombe R, Gornicki P, Greuer B, Mitchell P, Osswald M, Rinke-Appel J, Schüler D, Stade K.
    Journal: Biochim Biophys Acta; 1990 Aug 27; 1050(1-3):8-13. PubMed ID: 2207172.
    Abstract:
    A large number of intra-RNA and RNA-protein cross-link sites have been localized within the 23S RNA from E. coli 50 S ribosomal subunits. These sites, together with other data, are sufficient to constrain the secondary structure of the 23 S molecule into a compact three-dimensional shape. Some of the features of this structure are discussed, in particular, those relating to the orientation of tRNA on the 50 S subunit as studied by site-directed cross-linking techniques. A corresponding model for the 16S RNA within the 30 S subunit has already been described, and here a site-directed cross-linking approach is being used to determine the path followed through the subunit by messenger RNA.
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