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  • Title: [Oral oestro-progestative contraception and cervical and vaginal cytology (author's transl)].
    Author: Favre J, Siebert S, Drevet N.
    Journal: Sem Hop; ; 55(7-8):384-8. PubMed ID: 220729.
    Abstract:
    The cytological study of 1,685 smears belonging to women taking an oral contraception treatment, compared to 1,000 normal smears, shows that oestroprogestative drugs may be responsible for a certain number of more or less serious morphological disturbances in cervical and vaginal epithelial cells. These cell abnormalities, which correspond to inflammary of to slight dysphasia changes, are mostly spontaneously reversible or regress after cessation of the treatment. There does not seem to be a greater number of cervical cancers. This study investigates cytological smears from 1685 patients on oral contraception (OC) and compares them to 1000 smears from women not on OC. Most OC patients had been on combined OC, they were between 19-45, and had been treated for periods going from 2 months to 10 years. Cell anomalies were found in 67% of OC patients, and in 58% of controls. Benign anomalies concerned epithelial cells, endocervical cells, and Malpighi cells. Dysplasia was found in 3.6% of OC patients, and 1.4% of controls. Malignant cervical cancer cells were found in only 0.12% of OC patients, and 0.3% of controls. These data coincide with those from similar studies, and show that OC can cause a number of morphological disorders, more or less serious, in the cervico-vaginal cytology; these disorders, however, regress spontaneously after termination of OC.
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