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  • Title: Tandem one-pot synthesis of polysubstituted pyridines using the Blaise reaction intermediate and 1,3-enynes.
    Author: Chun YS, Lee JH, Kim JH, Ko YO, Lee SG.
    Journal: Org Lett; 2011 Dec 16; 13(24):6390-3. PubMed ID: 22074496.
    Abstract:
    A tandem one-pot method for the construction of a pyridine moiety with selective control of substitution patterns has been developed through the sequential reactions of nitrile with a Reformatsky reagent and 1,3-enyne involving regio- and chemoselective addition of the Blaise reaction intermediate to 1,3-enyne, followed by isomerization, cyclization, and an aromatization cascade.
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