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  • Title: Highly diastereoselective and enantioselective Michael addition of 5H-oxazol-4-ones to α,β-unsaturated ketones catalyzed by a new bifunctional organocatalyst with broad substrate scope and applicability.
    Author: Huang H, Zhu K, Wu W, Jin Z, Ye J.
    Journal: Chem Commun (Camb); 2012 Jan 11; 48(3):461-3. PubMed ID: 22075727.
    Abstract:
    A new thiourea-tertiary amine bifunctional catalyst derived from L-tert-leucine was developed and provides excellent stereocontrol in a novel and direct Michael addition of 5H-oxazol-4-ones to α,β-unsaturated ketones with much broad substrate scope. The conjugate addition products with chiral vicinal quaternary and tertiary stereocenters can be easily transformed to structurally interesting compounds or building blocks.
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