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  • Title: Design, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolase.
    Author: Pecic S, Deng SX, Morisseau C, Hammock BD, Landry DW.
    Journal: Bioorg Med Chem Lett; 2012 Jan 01; 22(1):601-5. PubMed ID: 22079754.
    Abstract:
    Inhibition of soluble epoxide hydrolase (sEH) has been proposed as a new pharmaceutical approach for treating hypertension and vascular inflammation. The most potent sEH inhibitors reported in literature to date are urea derivatives. However, these compounds have limited pharmacokinetic profiles. We investigated non-urea amide derivatives as sEH inhibitors and identified a potent human sEH inhibitor 14-34 having potency comparable to urea-based inhibitors.
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