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  • Title: Personalized medicine: changing the paradigm of drug development.
    Author: Couch RD, Mott BT.
    Journal: Methods Mol Biol; 2012; 823():367-78. PubMed ID: 22081358.
    Abstract:
    Despite an increased investment in research and development, there has been a steady decline in the number of drugs brought to market over the past 40 years. The tools of personalized medicine are refining diseases into molecular categories, and future therapeutics may be dictated by a patient's molecular profile relative to these categories. The adoption of a personalized medicine approach to drug development may improve the success rate by minimizing variability during each phase of the drug development process. This chapter describes the current paradigm of drug development and then discusses how molecular profiling/personalized medicine might be used to improve upon this paradigm.
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