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  • Title: [A man with blisters on hand and feet].
    Author: Gelderblom AJ, van der Rhee JI, Ouwerkerk J.
    Journal: Ned Tijdschr Geneeskd; 2011; 155(45):A3994. PubMed ID: 22085574.
    Abstract:
    A 41-year-old man with metastases of a gastrointestinal stroma tumour was treated with an angiogenesis inhibitor. He presented with a distinct painful erythematous hyperkeratotic bullous hand-foot skin reaction. This was thought to be caused by the oral angiogenesis inhibitor and resolved after discontinuation of the therapy. This is a known adverse effect of angiogenesis inhibitors and is dose dependent.
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