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  • Title: Impaired long-trace eyeblink conditioning in a Tg2576 mouse model of Alzheimer's disease.
    Author: Kishimoto Y, Oku I, Nishigawa A, Nishimoto A, Kirino Y.
    Journal: Neurosci Lett; 2012 Jan 06; 506(1):155-9. PubMed ID: 22085694.
    Abstract:
    Eyeblink conditioning has been used for assessing cognitive performance in cases of human neurodegenerative diseases including Alzheimer's disease (AD). Here, we tested and compared the delay and long-trace interval (TI=500ms) eyeblink conditionings in a Tg2576 mouse model of AD, at the age of 3, 6, and 12 months. Tg2576 mice exhibited significant impairment in trace conditioning at 6 months of age. In contrast, delay conditioning was not impaired in Tg2576 mice even at 12 months. These findings indicate that the long-TI eyeblink conditioning is more susceptible to age-related cognitive deterioration than delay conditioning in Tg2576 mice. The long-trace eyeblink conditioning could be a potential tool for detecting early cognitive deficits in AD mouse model.
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