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  • Title: Improvement of hyperandrogenism and hyperinsulinemia during pregnancy in women with polycystic ovary syndrome: possible effect in the ovarian follicular mass of their daughters.
    Author: Crisosto N, Echiburú B, Maliqueo M, Pérez V, Ladrón de Guevara A, Preisler J, Sánchez F, Sir-Petermann T.
    Journal: Fertil Steril; 2012 Jan; 97(1):218-24. PubMed ID: 22088206.
    Abstract:
    OBJECTIVE: To evaluate the ovarian function during early infancy in daughters of women with polycystic ovary syndrome (PCOS) treated with metformin throughout pregnancy (PCOSd+M), as a means to reduce androgen and insulin levels, compared with daughters of nontreated PCOS women (PCOSd-M) and daughters of women who belong to a healthy comparison group (HCd). DESIGN: Descriptive and analytic study. SETTING: Unit of endocrinology and reproductive medicine. PATIENT(S): Fifteen PCOSd+M, 23 PCOSd-M, and 35 HCd were studied at 2-3 months of age. INTERVENTION(S): A GnRH analogue test was performed with determinations of gonadotropins, sex steroids, SHBG, and anti-Müllerian hormone (AMH). MAIN OUTCOME MEASURE(S): Differences in AMH levels between PCOSd+M, PCOSd-M and HCd. RESULT(S): AMH and peak E(2) concentrations were significantly higher in PCOSd-M compared with HCd, whereas PCOSd+M exhibited AMH concentrations and peak E(2) levels similar to those observed in HCd. CONCLUSION(S): The improvement of the altered endocrine-metabolic environment of PCOS mothers reduces AMH levels in their daughters, which might reflect a decrease in their follicular mass.
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