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  • Title: Vascular retention of saline following acute and subacute hemorrhage in dogs.
    Author: Levy M.
    Journal: Clin Invest Med; 1990 Aug; 13(4):178-82. PubMed ID: 2208833.
    Abstract:
    Acute hemorrhage is usually associated with compensatory mechanisms calculated to replenish the vascular compartment. In the present study, we studied the transvascular distribution of an isotonic saline load (7% body weight) delivered to supine anaesthetized dogs following acute (20-25 ml/kg blood removed on the morning of the study) or subacute (20-25 ml/kg blood removed 16-18 h before the study) hemorrhage. In 10 dogs subjected to subacute hemorrhage, plasma volume was unaltered from control values 3 h post-load, and 6/10 animals also lost original plasma volume. Only 5.8% of the anticipated volume was retained within the vascular space. The percentage of extracellular fluid (ECF) partitioned as plasma declined from 33 to 23% (p less than 0.05). In 6 dogs with acute hemorrhage treated the same way, plasma volume increased by 24% at 3 h post-loading and 59.8% of the available volume now remained intravascularly. The percentage of ECF partitioned as plasma declined from 30 to 26%, a change of only 13% compared to a decline of 30% observed for the subacute group. We conclude that a delay in replenishing the ECF following hemorrhage may profoundly alter the volume of infused isotonic saline retained within the vascular compartment.
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