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  • Title: Novel transplant strategies in adults with acute leukemia.
    Author: Paun O, Lazarus HM.
    Journal: Hematol Oncol Clin North Am; 2011 Dec; 25(6):1319-39, ix. PubMed ID: 22093589.
    Abstract:
    Autologous and allogeneic hematopoietic cell transplantation (HCT) is regularly used as a curative treatment option for patients with various disorders, including acute leukemia in adults. The past decade has witnessed dramatic improvements in the reduction of treatment-related mortality (TRM), in part attributable to improved supportive care but also due to better graft selection and donor-to-recipient matching regimens, and the emergence of reduced-intensity conditioning in place of myeloablative conditioning. Despite these advances, HCT remains plagued by the risk of relapse or failure due to graft-versus-host disease, infectious complications, and TRM. This article reviews new approaches that may improve overall patient outcome.
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