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  • Title: [Puerarin induced apoptosis of pulmonary artery smooth muscle cell by mitochondrial pathway].
    Author: Zhang X, Zhao F, Zhang X, Sheng J.
    Journal: Zhongguo Zhong Yao Za Zhi; 2011 Aug; 36(16):2255-8. PubMed ID: 22097342.
    Abstract:
    OBJECTIVE: To investigate the contribution of mitochondrial pathway in the apoptosis induced by puerarin (PUE) in pulmonary artery smooth muscle cells. METHOD: Cultured rat pulmonary artery smooth muscle cells (PASMC) were intervened by high, middle and low dose of puerarin (1.5 x 10(-3), 1.5 x 10(-4), 1.5 x 10(-5) mol x L(-1)). The change of mitochondrial membrane potential was observed. Western blot detected the expression of apoptosis-related gene Caspase-9, Bax and Bcl-2 protein. RESULT: Compared with the control group, mitochondrial membrane potential significantly decreased in puerarin groups. Puerarin can enhance the expression of Caspase-9 and Bax protein, decrease the expression of Bcl-2 protein. Puerarin also has a concentration-dependent on the induction of PASMC. CONCLUSION: Puerarin can induce PASMC apoptosis through mitochondrial pathway.
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