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  • Title: Early cholecystectomy and ERCP are associated with reduced readmissions for acute biliary pancreatitis: a nationwide, population-based study.
    Author: Nguyen GC, Rosenberg M, Chong RY, Chong CA.
    Journal: Gastrointest Endosc; 2012 Jan; 75(1):47-55. PubMed ID: 22100300.
    Abstract:
    BACKGROUND: Cholecystectomy is recommended during hospitalizations for acute biliary pancreatitis (ABP). OBJECTIVE: We sought to assess the population-based effectiveness of index cholecystectomy by using nationwide data. DESIGN: Retrospective, cohort study. SETTING: All acute-care hospitals in Canada from 2007 to 2010. PATIENTS: This study involved patients admitted for ABP in the Canadian Institutes for Health Information hospital discharge database. INTERVENTION: Cholecystectomy and therapeutic ERCP during the index admission. MAIN OUTCOME MEASUREMENTS: Rate of hospital readmissions for ABP. RESULTS: Among 5646 patients with ABP, 32% underwent cholecystectomy and 22% ERCP during the index admissions. Patients admitted to hospitals in the highest quartile for cholecystectomy volume were more than 10-fold likely to undergo cholecystectomy during the index admission (adjusted odds ratio 11.0; 95% confidence interval [CI], 7.4-16.5). The 12-month readmission rate for ABP was lower with cholecystectomy (5.6% vs 14.0%; P < .0001) and therapeutic ERCP (5.1% vs 13.1%; P < .0001). After multivariate adjustment, lower readmission rates were independently associated with both cholecystectomy (adjusted hazard ratio [HR] 0.39; 95% CI, 0.32-0.48) and ERCP (adjusted HR 0.37; 95% CI, 0.29-0.50). After excluding early readmissions (within 28 days of discharge), the adjusted HR for cholecystectomy was 0.43 (95% CI, 0.34-0.57). The admitting hospital's cholecystectomy volume was inversely associated with 12-month readmission rates for ABP (quartile 1, 15.9%; quartile 2, 13.9%; quartile 3, 11.3%; quartile 4, 10.0%; P < .001). LIMITATIONS: The study was based on hospital administrative data. CONCLUSION: Cholecystectomy and ERCP during the index admission were associated with reduced readmission rates for ABP, providing population-based evidence to support consensus guidelines that recommend early biliary intervention.
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