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  • Title: Hereditary thrombophilia, anti-beta2 glycoprotein 1 IgM, and anti-annexin V antibodies in recurrent pregnancy loss.
    Author: Karata S, Aydin Y, Ocer F, Buyru A, Balci H.
    Journal: Am J Reprod Immunol; 2012 Mar; 67(3):251-5. PubMed ID: 22103678.
    Abstract:
    PROBLEM: We investigated the beta2-glycoprotein I and anti-annexin V antibodies as anti-phospholipid-cofactor antibodies; and factor V G1691A Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase (MTHFR) C677T mutations as hereditary thrombophilia in recurrent pregnancy losses (RPL). METHOD OF STUDY: Study group consisted of 84 women with recurrent pregnancy loss and control group consisted of 84 women having at least one live birth. RESULTS: Methylenetetrahydrofolate reductase C677T homozygous mutation was detected in 28.5% of the study group and in 14.2% of the controls, and the difference was highly significant (P < 0.001). Heterozygous mutation of this gene was found in 64.3% of the study population and in 38.1% of the controls, and difference in heterozygous mutation frequency was also significant (P < 0.001). Both homozygous and heterozygous mutations of PT G20210A and factor V G1691A were not different between the groups. There was no significant difference in anti-annexin V levels and anti-beta2-gp 1 levels of the groups. CONCLUSION: We concluded that both homozygous and heterozygous mutations of MTHFR C677T were related with RPL in Caucasian women.
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