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  • Title: Central nervous system regeneration does not occur.
    Author: Illis LS.
    Journal: Spinal Cord; 2012 Apr; 50(4):259-63. PubMed ID: 22105462.
    Abstract:
    STUDY DESIGN: Review. OBJECTIVES: To examine the state of research in central nervous system (CNS) regeneration and to suggest an alternative to the sterile research at the lesion site. SETTING: Worldwide. METHODS: A search of publications using 'PubMed' and a search of the historical literature relevant to CNS regeneration, biological models, the neurone theory, collateral sprouting, spinal shock and the central pattern generator. RESULTS: There is no evidence for CNS regeneration. CONCLUSION: A century of research focussed on the lesion site has been unproductive. An alternative field of research must be developed and the best candidate is the undamaged CNS.
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