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  • Title: Reversal by glucocorticoid hormones of the loss of a fibronectin and probollagen matrix around transformed human cells.
    Author: Furcht LT, Mosher DF, Wendelschafer-Crabb G, Foidart JM.
    Journal: Cancer Res; 1979 Jun; 39(6 Pt 1):2077-83. PubMed ID: 221101.
    Abstract:
    Confluent cultured human skin fibroblasts had an extracellular fibrillar matrix of fibronectin and procollagen. Human skin fibroblasts transformed by SV40 did not have such a matrix. Treatment of transformed fibroblasts with 10(-5) to 10(-8) M dexamethasone and 10(-5) to 10(-7) M cortisol, but not testosterone or progesterone, caused partial restoration of the matrix. Glucocorticoid-treated transformed human fibroblasts can serve as a model for partial reversion toward normal or differentiation of transformed human fibroblasts.
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