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  • Title: Lipase-catalyzed kinetic resolution of aryltrimethylsilyl chiral alcohols.
    Author: Palmeira DJ, Abreu JC, Andrade LH.
    Journal: Molecules; 2011 Nov 23; 16(11):9697-713. PubMed ID: 22113578.
    Abstract:
    Lipase-catalyzed kinetic resolution of aryltrimethylsilyl chiral alcohols through a transesterification reaction was studied. The optimal conditions found for the kinetic resolution of m- and p-aryltrimethylsilyl chiral alcohols, led to excellent results, high conversions (c = 50%), high enantiomeric ratios (E > 200) and enantiomeric excesses for the remaining (S)-alcohol and (R)-acetylated product (>99%). However, kinetic resolution of o-aryltrimethylsilyl chiral alcohols did not occur under the same conditions applied to the other isomers.
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