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  • Title: Trypanocidal activity of oxoaporphine and pyrimidine-β-carboline alkaloids from the branches of Annona foetida Mart. (Annonaceae).
    Author: Costa EV, Pinheiro ML, de Souza AD, Barison A, Campos FR, Valdez RH, Ueda-Nakamura T, Filho BP, Nakamura CV.
    Journal: Molecules; 2011 Nov 23; 16(11):9714-20. PubMed ID: 22113579.
    Abstract:
    Phytochemical investigation of the branches of Annona foetida Mart. led to isolation from the CH(2)Cl(2) extract of four alkaloids: Atherospermidine (1), described for the first time in this species, liriodenine (2), O-methylmoschatoline (3), and annomontine (4). Their chemical structures were established on the basis of spectroscopic data from IR, MS, NMR (1D and 2D), and comparison with the literature. Compounds 2-4 showed potent trypanocidal effect when evaluated against epimastigote and trypomastigote forms of Trypanosoma cruzi.
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