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  • Title: In-vitro activity of PD 117 596, a new quinolone, against bacterial isolates from cancer patients.
    Author: Rolston KV, LeBlanc B, Ho DH, Bodey GP.
    Journal: J Antimicrob Chemother; 1990 Jul; 26(1):39-44. PubMed ID: 2211445.
    Abstract:
    The in-vitro activity of PD117 596, a new 4-quinolone antimicrobial agent was compared with that of ciprofloxacin against 798 Gram-positive and Gram-negative distinct isolates from cancer patients. PD117 596 was found to have a broad antimicrobial spectrum with excellent activity against the Enterobacteriaceae (MIC90 0.03 mg/l) Acinetobacter spp. (MIC90 0.25 mg/l), Aeromonas spp. (MIC100 0.06 mg/l) and Pseudomonas spp. including Ps. aeruginosa (MIC90 0.5 mg/l). It was also extremely active against Gram-positive micro-organisms particularly Staphylococcus spp. (including methicillin-resistant and coagulase-negative isolates) Bacillus spp. and streptococci. PD117 596 had lower minimal inhibitory concentrations against most isolates tested than ciprofloxacin, the most active currently available 4-quinolone.
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