These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Increased deep sleep after trazodone use: a double-blind placebo-controlled study in healthy young adults.
    Author: Ware JC, Pittard JT.
    Journal: J Clin Psychiatry; 1990 Sep; 51 Suppl():18-22. PubMed ID: 2211560.
    Abstract:
    The effects of trazodone on sleep were compared with those of placebo and the sedating tricyclic antidepressant trimipramine in a double-blind crossover study in six healthy young men. Only trazodone significantly increased deep sleep without otherwise altering the normal architecture of sleep. The alpha-adrenergic receptor-blocking property of trazodone and a relative lack of noradrenergic reuptake blocking and the lack of anticholinergic effects are hypothesized to be responsible for the effects on sleep.
    [Abstract] [Full Text] [Related] [New Search]