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  • Title: Direct molecule-specific glucose detection by Raman spectroscopy based on photonic crystal fiber.
    Author: Yang X, Zhang AY, Wheeler DA, Bond TC, Gu C, Li Y.
    Journal: Anal Bioanal Chem; 2012 Jan; 402(2):687-91. PubMed ID: 22120042.
    Abstract:
    This paper reports the first step toward the development of a glucose biosensor based on Raman spectroscopy and a photonic crystal fiber (PCF) probe. Historically, it has been very challenging to detect glucose directly by Raman spectroscopy due to its inherently small Raman scattering cross-section. In this work, we report the first quantitative glucose Raman detection in the physiological concentration range (0-25 mM) with a low laser power (2 mW), a short integration time (30 s), and an extremely small sampling volume (~50 nL) using the highly sensitive liquid-filled PCF probe. As a proof of concept, we also demonstrate the molecular specificity of this technique in the presence of a competing sugar, such as fructose. High sensitivity, flexibility, reproducibility, low cost, small sampling volume, and in situ remote sensing capability make PCF a very powerful platform for potential glucose detection based on Raman spectroscopy.
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